Prevalence estimation and optimal classification methods to account for time dependence in antibody levelsArticle Published on 2023-02-212023-07-11 Journal: Journal of theoretical biology [Category] COVID19(2023년), [키워드] Antibody testing optimization Prevalence estimation SARS-CoV-2 Time-dependent classification. [DOI] 10.1016/j.jtbi.2022.111375 PMC 바로가기
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signatureArticle Published on 2022-12-212023-07-11 Journal: Cell Systems [Category] COVID19(2023년), [키워드] COVID-19 cross-reactivity epigenomics host response signature interpretability optimization plasmablasts robustness transcriptomics viral infection diagnosis. [DOI] 10.1016/j.cels.2022.11.008 PMC 바로가기
Real-Time fast PCR amplification using designated and conventional real time thermal cycler systems: COVID-19 perspectiveArticle Published on 2022-10-202022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ABI ABI 7500 Applied Biosystem approach approach Bio-rad comparable comparison Conventional COVID-19 COVID-19 sample detection did not produce Dilution human RP mRNA multiplex N1 and N2 optimization PCR PCR amplification Perspective positive control Precision protocol real time RNase P RT-PCR SARS CoV-2 sensitivity Sensitivity and specificity sequence specificity Standard System the median time touch was done was performed [DOI] 10.1371/journal.pone.0276464 PMC 바로가기
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a PhotosensitizerArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] anti-inflammatory properties Antiviral approach Cell culture cells Concentration COVID-19 Curcuma Curcumin dose effective immunomodulatory in vitro In vitro infection inhibited optimization photodynamic therapy photodynamic therapy. photosensitizer prophylactic treatment reduction reported RNase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication suggested therapy Treatment Vero E6 VERO E6 cells virion virus virus inactivation [DOI] 10.3390/v14102132 PMC 바로가기
Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 ActivityArticle Published on 2022-09-222022-11-15 Journal: Journal of medicinal chemistry [Category] SARS, 변종, 치료제, [키워드] Activation activity analogue antiviral activity antiviral drug antiviral potency Antiviral treatment Concentration COVID-19 COVID-19 patient Efficacy FDA-approved drug hamsters hydrolysis lack lung lung epithelial cell Lungs metabolite moiety NTP nucleoside optimization Patient patients plasma Premature prodrug reducing Remdesivir severe symptom severe symptoms tissue treat variants of SARS-CoV-2 [DOI] 10.1021/acs.jmedchem.2c00758 PMC 바로가기
Optimization of COVID-19 prevention and control measures during the Beijing 2022 Winter Olympics: a model-based studyArticle Published on 2022-09-062022-11-15 Journal: Infectious Diseases of Poverty [Category] SARS, 치료기술, [키워드] acute respiratory syndrome assumed baseline levels Beijing Combination Comprehensive Contact coronavirus coronavirus disease COVID-19 COVID-19 transmission cumulative dynamic Dynamic model Epidemic evaluate the effect health monitoring Hospitalized Infection Intervention Isolation management measure medical resource Mutation nucleic acid optimization pandemic parameter predict Prevent Prevention and control Prevention and control measure provided pulse reached reducing reduction Research risk sensitivity analysis Spread The Beijing 2022 Winter Olympics. the epidemic Transmission Transmission dynamics virus transmission Winter [DOI] 10.1186/s40249-022-01019-2 PMC 바로가기
Optimization of peripheral blood volume for in silico reconstitution of the human B-cell receptor repertoireArticle Published on 2022-09-012022-11-15 Journal: FEBS Open Bio [Category] SARS, 진단, 치료기술, [키워드] Analysis anatomical antibodies antibody Antigen Autoimmune disease B cell B cell receptor repertoire B-cell BCR BCR-based diagnostics calculated change clinically correlation Diagnosis diagnostic Frequency functional FUS HIV human B-cell in silico Next-generation sequencing no increase observation optimization pathology Peripheral blood peripheral blood. prognostic receptor recognize reduced SARS-CoV2 sequence significantly higher slight increase statistically significant Support unique Volume volunteers [DOI] 10.1002/2211-5463.13467 PMC 바로가기
Directional mutation and crossover boosted ant colony optimization with application to COVID-19 X-ray image segmentationResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, 치료기술, [키워드] Accuracy ACO Algorithm Ant colony optimization competing COVID-19 COVID-19 X-ray directional ENhance experiment experiments faster Image segmentation IMPROVE increase Local Mutation optimization Other Swarm intelligence threshold two-dimensional Validity were used X-ray [DOI] 10.1016/j.compbiomed.2022.105810 [Article Type] Research article
Evaluating Effects of Dynamic Interventions to Control COVID-19 Pandemic: A Case Study of Guangdong, ChinaCOVID-19 전염병 통제를 위한 동적 개입의 효과 평가: 중국 광둥 사례 연구Article Published on 2022-08-162022-09-11 Journal: International Journal of Environmental Research an [Category] 변종, [키워드] Accuracy adaptive Algorithm applied chain China comparable Control COVID-19 COVID-19 epidemic COVID-19 transmission dynamic dynamic intervention Effect Effectiveness Efficiency efficiency evaluation Epidemic epidemiological evaluate Evaluating Guangdong Guangzhou iLSEIR-DRAM model inflection point Intervention Logistic logistic function Markov Markov chain optimization parameter Prevention and control promote Quantitative rejection SEIR Seven susceptible-exposed-infected-removed the epidemic transmission rate transmission rate. virus variants [DOI] 10.3390/ijerph191610154 PMC 바로가기 [Article Type] Article